The CJC-1295 + ipamorelin stack: what is known
Every row cites its source. Where a cell reflects our own reading of the evidence rather than an external source, the row says so.
| Dimension | CJC-1295 | Ipamorelin (as the stack partner) | Source |
|---|---|---|---|
| Receptor logic | GHRH-receptor agonist: supplies the releasing signal | Selective ghrelin-receptor (GHS-R) agonist: pulls the second lever; released GH without raising ACTH or cortisol in animal studies | source |
| Documented synergy | For the receptor classes: GHRP-6 plus GHRH showed enhanced GH secretion in humans | For this specific pair: never tested in any clinical trial | source |
| Combination trials | None registered for CJC-1295 with anything | None for the stack; 2026 review: anecdotal rationale, limited controlled evidence | source |
| FDA posture | On the compounding safety-risks list; serious AE reports (heart rate, vasodilation) | On the same list; FDA cites a published report of serious adverse events including death with IV use in a hospital motility program | source |
| Typical forum pattern | No-DAC form 100 to 200 mcg with ipamorelin, once or twice daily (documented by review; education only) | 200 to 300 mcg two to three times daily alongside the GRF partner (same source) | source |
| What stacking adds to risk | Unknown: stacked GH-axis exposure is exactly the pattern 2026 reviews flag as unstudied, on products of unverified content | Same unknown, squared by the second compound | source |
The most-marketed pairing in the GH-peptide world rests on real receptor physiology and zero combination trials. This is an education row, not a comparison of equals: it maps exactly which parts of the stack story are documented, and where the evidence stops. Our sister site ipamorelinco.com covers ipamorelin itself in full.
Ipamorelin's own evidence record (including its failed clinical development for postoperative ileus) belongs to the ipamorelin monograph on our sister site; this table cites only the FDA page, the 1998 pharmacology paper, and the 2026 review fetched for this pack.
Researching Ipamorelin (as the stack partner) itself? Its dedicated guide site is at ipamorelinco.com.